All About Restless Legs Syndrome (RLS)
Restless Legs Syndrome (RLS) is a neurologic sensorimotor disorder that is characterized by an overwhelming urge to move the legs
when they are at rest. The urge to move the legs is usually, but not always, accompanied by unpleasant sensations. It is less common
but possible to have RLS symptoms in the arms, face, torso, and genital region. RLS symptoms occur during inactivity and they are
temporarily relieved by movement or pressure. Symptoms of RLS are most severe in the evening and nighttime hours and can
profoundly disrupt a patient's sleep and daily life.
RLS affects approximately 10% of adults in the U.S. Researchers believe that RLS is commonly unrecognized or misdiagnosed as
insomnia or other neurological, muscular or orthopedic condition. RLS may also be confused with depression. According to the Restless
Legs Syndrome Foundation, approximately 40% of people with RLS complain of symptoms that would indicate depression if assessed
without knowledge or consideration of a sleep disorder.
RLS runs in families and may have a genetic component. In a recent study, the first RLS gene was discovered and was shown to
account for approximately 50% of RLS cases. However, the researchers who identified the RLS gene cautioned that having it does not
guarantee RLS. Rather, there are likely to be medical, environmental or other factors involved in translating RLS genetic susceptibility
into RLS symptoms. Another recent RLS study also found that a genetic variant may account for about half of RLS cases and revealed
an association between RLS and a gene for limb development, suggesting the possibility that RLS has components of a developmental
RLS also affects about 2% of children, according to a recent study of more than 10,000 families in the U.S. and U.K. The study also
found a strong genetic component to RLS; more than 70% of children with RLS had at least one parent with the condition. There is also
evidence suggesting that children with attention deficit hyperactivity disorder (ADHD) and a family history of RLS are at risk for more
RLS affects both men and women and can start at any age. It may be confused with growing pains or restlessness when experienced by
children. In addition, the severity of the disorder appears to increase with age. Older patients experience symptoms more frequently and
for longer periods of time.
The exact cause of RLS is unknown but it has a primary form, not related to other disorders, and a secondary form related to an
underlying condition such as kidney failure, pregnancy, or iron deficiency anemia. It may also be caused or made worse by certain
medications. This is considered secondary RLS. When no other cause is found for RLS symptoms, it is considered a primary disorder.
Primary RLS accounts for 40-60% of RLS diagnoses.
Recently, several research teams have taken a closer look at what might cause primary RLS. In particular, recent studies at Johns
Hopkins and Pennsylvania State Colleges have found evidence for brain iron deficiency as a cause for primary RLS. This was first
demonstrated in cerebrospinal fluid studies and more recently by the first-ever autopsy analysis of the brains of people with RLS. The
autopsy studies reported that cells from the portion of the brain called the substantia nigra showed a deficit in one of the proteins that
regulates iron status. However, this evidence suggests that the iron insufficiency in the brain of RLS patients comes directly from a
failure of normal iron regulation. In terms of finding a cure, this is good news. The results of this study show that there is no brain
damage in people with RLS and that drugs that target the problem of iron uptake may be one way to approach future developments of a
More than 80 percent of people with RLS also suffer from a condition know as periodic limb movement disorder (PLMD). Characteristics
of PLMD include involuntary leg twitching or jerking movements during sleep that occur repeatedly throughout the night and result in
In addition to poor quality and short sleep at night, research has shown that people with RLS generally experience a reduced quality of
life in the absence of treatment.
American Sleep and Epilepsy Centers
Restless Legs Syndrome